Leptin Protects Host Cells from Entamoeba histolytica Cytotoxicity by a STAT3-Dependent Mechanism
نویسندگان
چکیده
منابع مشابه
Leptin protects host cells from Entamoeba histolytica cytotoxicity by a STAT3-dependent mechanism.
The adipocytokine leptin links nutritional status to immune function. Leptin signaling protects from amebiasis, but the molecular mechanism is not understood. We developed an in vitro model of ameba-host cell interaction to test the hypothesis that leptin prevents ameba-induced apoptosis in host epithelial cells. We demonstrated that activation of mammalian leptin signaling increased cellular r...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2012
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.06140-11